Other Names: Optic atrophy, infantile hereditary, Behr complicated form of; Optic atrophy in early childhood, associated with ataxia, spasticity, mental retardation, and posterior column sensory loss

 

Behr syndrome is characterized by the association of early-onset optic atrophy with spinocerebellar degeneration resulting in ataxia, pyramidal signs, peripheral neuropathy and developmental delay. Although it is an autosomal recessive disorder, heterozygotes may still manifest much attenuated symptoms. Autosomal dominant inheritance also being reported in a family. Recently a variant of OPA1 mutation with phenotypic presentation like Behr syndrome is also described.  Some reported cases have been found to carry mutations in the OPA1, OPA3 or C12ORF65 genes which are known causes of pure optic atrophy or optic atrophy complicated by movement disorder.

Contact the Genetic and Rare Diseases (GARD) Information Center for more information on Behr Syndrome.