Epidemiology of Covid-19 in a Long-Term Care Facility in King County, Washington
Dr. McMichael and colleagues provided a detailed assessment of the persons who became infected with Covid-19 in a long-term care facility in Seattle, Washington.
As of March 18, there were 167 confirmed cases affecting 1010 residents, 50 health care personnel and 16 visitors. Among the elderly residents, the fatality rate was 33.7% vs 6.2% for visitors. No staff members died as a result of the infection.
To read the study in the New England Journal of Medicine, click here.
Leflunomide–Hydroxychloroquine Combination Therapy in Patients With Primary Sjögren’s Syndrome (RepurpSS-I): A Placebo-Controlled, Double-Blinded, Randomised Clinical Trial
van der Heijden et al published their results of a phase 2 clinical trial showing the combination Leflunomide–hydroxychloroquine to be safe and resulted in a clinical response in patients with primary Sjögren’s syndrome.
To read the study in Lancet Rheumatology, click here.
A Phase 3 Trial of Luspatercept in Patients With Transfusion-Dependent β-Thalassemia
Cappellini and colleagues published the results of their phase 3 clinical trial showing luspatercept to reduce transfusion burden in person the transfusion-dependent ß-thalassemia.
To read the article published in the New England Journal of Medicine, click here.
The Effect of Human Gene Therapy for RPE65-Associated Leber’s Congenital Amaurosis on Visual Function: A Systematic Review and Meta-Analysis
Wang et al provided a review of the safety and efficacy of gene therapy on visual function on patients with RPE65-associated Leber’s congenital amaurosis.
To read the article in the Orphanet Journal of Rare Diseases, click here.
Health, Well Being and Lived Experiences of Adults With SMA: A Scoping Systematic Review
Wan and colleagues looked at the wellbeing of that with SMA Spinal muscular atrophy – a rare neurodegenerative disease that requires a plethora of support for persons as the disease progresses.
To view the article in the Orphanet Journal of Rare Diseases, click here.
