Professor Ulla Feldt-Rasmussen, MD, Department of Medical Endocrinology and Metabolism, Rigshospitalet Copenhagen University Hospital, gives an overview of hypothalamic obesity (HO). 

HO is a rare endocrine disorder characterized by severe and debilitating obesity. Signs and symptoms of hypothalamic obesity include excessive appetite, inability to feel ‘full’, and rapid weight gain. Additionally, people with HO tend to have a low metabolic rate, decreased physical activity, and excessive daytime sleepiness. Currently, there are no approved treatments specifically for HO. Standard treatment approaches for HO such as surgery, medication, and lifestyle counseling have been mostly ineffective. However, results from a phase 2 trial of the developmental drug, testomet, are positive.

For more information about HO and other rare endocrine disorders, visit