Joel, a patient with thrombotic thrombocytopenic purpura (TTP) describes the common symptoms of this rare, hematologic condition.

Acquired TTP is a potentially life-threatening, thrombotic micro-angiopathy due to decreased activity of ADAMTS13, the von Willebrand factor-cleaving protease. Decrease activity of this enzyme leads to an accumulation of ULvWF multimers which bind to platelets and induce aggregation. The net result is severe thrombocytopenia, tissue ischemia, and organ dysfunction that can be life-threatening. 

As Joel explains in this video, a common symptom is severe exhaustion, but fever, headache, confusion, and bruises or dots on the skin are also usually present during an episode.

For more information about TTP and other hematologic conditions, visit hematologic-disorders/