Ruth-Anne Langan Pai, PHD Candidate and the collaborative research project lead for the Castleman Disease Collaborative Network (CDCN) provides an overview of Castleman disease.

Castleman disease is a group of rare disorders characterized by lymph node enlargement, specific microscopic changes to the lymph nodes, and a range of symptoms and laboratory findings.

There are 3 types of Castleman disease: (1) unicentric Castleman disease, (2) HHV-8 positive multicentric Castleman disease, and (3) idiopathic multicentric Castleman disease.

Symptoms vary with each person but may include the following:

  • Flu-like symptoms
  • Unintended weight loss
  • Weakness and fatigue
  • Enlarged liver or spleen
  • Peripheral neuropathy
  • Cherry hemangiomas skin rash
  • Edema, ascites and/or other symptoms of fluid overload
  • Kidney dysfunction

To learn more about this and other rare hematologic conditions, visit

To learn more about CDCN, visit


  • Sign up
Lost your password? Please enter your username or email address. You will receive a link to create a new password via email.
We do not share your personal details with anyone.