Julia Warren, MD, Ph.D., Associate Professor of Hematology at the University of Pennsylvania and Hematologist at Children’s Hospital of Philadelphia, gives an overview of chronic neutropenic disorders.
Chronic neutropenic disorders are blood disorders characterized by low levels of neutrophils. These disorders are associated with an increased risk of recurrent and/or severe infections. The most common forms are chronic idiopathic neutropenia, cyclic neutropenia, and severe congenital neutropenia. The current management strategy for chronic neutropenia is long-term treatment with injectable granulocyte colony-stimulating factor (G-CSF).
As Dr. Warren explains, the reduction in neutrophils makes persons more susceptible to severe infections, as well as a plethora of symptoms that can develop, including mouth sores, fatigue, and gastrointestinal problems.
Recently, positive results of a phase 1b trial evaluating mavorixafor in across patients with chronic neutropenic disorders were presented at the most recent American Society of Hematology Meeting & Exposition (ASH 2022).
To learn more about chronic neutropenic disorders and other rare hematological disorders, visit https://checkrare.com/diseases/hematologic-disorders/
