Rakesh Jain, MD, MPH, Clinical Professor of Psychiatry, discusses tardive dyskinesia (TD) data from the IMPACT-TD Registry study.
TD is a rare neurological disorder characterized by involuntary and repetitive movements, often involving muscles in the face, torso, or other areas. The disorder is often a side effect of medicines used in treating mental health disorders.
IMPACT-TD Registry Trial
The IMPACT-TD study is a three-year, longitudinal, observational study evaluating the progression and quality of life impact of TD. It additionally evaluates outcomes of treatment with Austedo XR (deutetrabenazine). Deutetrabenazine is a vesicular monoamine transporter 2 (VMAT2) inhibitor approved by the U.S. Food and Drug Administration for the treatment of adults with TD and chorea associated with Huntington’s disease.
Data from the study revealed that fewer people with psychotic disorders received a TD diagnosis compared to those with mood disorders, despite having similar mean AIMS scores (8.7 vs 8.0), longer median time since first recognition of movements (5.5 years vs 3.8 years), and longer median time since first use of an antipsychotic (16 vs 10 years). Patients with psychotic disorders were also more likely to be younger, Black or African American, and male.
Despite these results, the impact of TD was similar in those with psychotic disorders and those with mood disorders, with moderate to severe impact in 86% and 80% respectively.
Real World Evidence
Data was also presented on real-world patient experiences with deutetrabenazine in adults with TD and Huntington’s disease chorea. Of 131 respondents, 87% reported satisfaction with the medication, 74% reported improvements in extra movements, and 76% reported that these reductions improved comfort in social settings and emotional well-being. 98% stated that the medication was easy to use and 95% reported plans to continue treatment with the medication.
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Tag: Neuro, musculoskeletal, treatment