Raymond Douglas, MD, PhD, at the Cedars-Sinai Medical Center explains thyroid eye disease (TED).
TED is a rare autoimmune disease that can dramatically impact a person’s vision. The condition often occurs in people with hyperthyroidism or Graves’ disease. Common symptoms can include upper eyelid retraction, dry eyes, inflammation, light sensitivity, as well as the sensation of a foreign body present in the eye.
Persons with TED have autoantibodies that activate an IGF-1R-mediated signaling complex on cells within the retro-orbital space. Teprotumumab-trbw blocks IGF-1R and is approved to treat persons with TED.
To learn more about TED and other autoimmune disorders, click here.